Biology at Scale: From Variants to Cellular Programs and Functions

About

The British Society for Genetic Medicine provides a forum for professionals involved in genetics and genomics as a clinical service and research.

As an umbrella organisation, our membership includes a wide spectrum of clinical, laboratory and research disciplines, not only in specialist genetic services but throughout the health professions.

The Joint Committee on Genomics in Medicine

The Joint Committee on Genomics in Medicine is a tripartite committee of the BSGM, RCPath and RCP, with representation from other professional bodies and patient organisations. It provides a unified forum to co-ordinate activities across a wide spectrum of organisations, particularly to promote and maintain the highest standards of practice in clinical and laboratory applications of genetics in medicine and to co-ordinate advice on service issues and workforce planning.

For its remit, membership, and minutes, please visit

This new conference will bring together world leaders to discuss the integration of cutting-edge technologies and the development of analytical methods that can bridge the gap between genetics, cell biology, and human health to tackle a key challenge: linking polygenic signals to mechanistic insights. The scope of the meeting is to go beyond variant curation or single-gene models, to showcase frameworks that are context-aware, scalable and multimodal. Sessions will feature advances in high-resolution trait mapping, functional genomics, and causal inference, spanning CRISPR-based perturbation screens, single-cell phenotyping, spatial transcriptomics, and high-content imaging. The programme will emphasise how these diverse technologies can be integrated into scalable frameworks that move beyond transcriptomic readouts to capture the true complexity of genetic effects. By fostering cross-disciplinary collaboration, the meeting will enable the development and application of methods and approaches that connect polygenic signals to gene programs, cellular mechanisms, and functional insight. Attendees will gain fresh perspectives on bridging genotype to function, with opportunities to engage through keynote talks from global leaders, selected short talks, and poster presentations. The conference will also provide unique networking opportunities, fostering discussions, collaborations, and connections across diverse research communities.